Protein Details: Gamma-aminobutyric acid receptor subunit pi

Function

Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA). GABA-gated chloride channels; also named GABA(A) receptors (GABAAR); consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA; GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Pi-containing GABAARs are mostly located in peripheral tissues. In the uterus; pi subunits modulate uterus contraction by altering the sensitivity of GABAARs to pregnanolone (By similarity). In the lungs; pi-containing GABAARs contribute to pulmonary fluid transport via luminal secretion of chloride.

Sequence

PDB Structures

Ligand Binding